Results
| PMID | 27137486 |
| Gene Name | C3 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 23 |
| Population details | 23 (20 endometriosis patients, 3 healthy controls) |
| Age | Median age: 32yrs |
| Sex | Female |
| Associated genes | AZGP1, C3 |
| Other associated phenotypes |
Endometriosis |
|
J Cell Physiol. 2016 Dec;231(12):2622-7. doi: 10.1002/jcp.25410. Epub 2016 May Signorile, Pietro Giulio| Baldi, Alfonso Centro Italiano Endometriosi, Rome, Italy.| Centro Italiano Endometriosi, Rome, Italy. Endometriosis is a very common disease, affecting 10% of women in the reproductive age. To date, a significant delay between onset of the symptoms and definitive diagnosis is caused by the lack of a reliable non-invasive diagnostic test. Recently, the potential value as diagnostic markers for endometriosis of three proteins (Zn-alpha2-glycoprotein, serum albumin, and complement C3 precursor), has been showed. In this article, we have defined the experimental conditions for the development of a multiplex bead array assay for rapid and simultaneous quantification of these three biomarkers in the serum of patients with endometriosis. Finally, pivotal experiments on a small cohort of patients have confirmed the diagnostic value of this assay. J. Cell. Physiol. 231: 2622-2627, 2016. (c) 2016 Wiley Periodicals, Inc. Mesh Terms: Adult| Biological Assay/*methods| Biomarkers/*blood| Calibration| Carrier Proteins/blood| Case-Control Studies| Complement C3/metabolism| Endometriosis/*blood/*diagnosis| Female| Glycoproteins/blood| Humans| Protein Binding| Serum Albumin/meta |
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